Amino acids are a class of compounds with wide-ranging applications. The synthesis of amino acids from biomass-derived α-keto acids and ammonia is a sustainable way but the unstable primary imine intermediates (R-C=NH) easily form oligomers. Herein, targeting this problem, alkaline modified mesoporous silica was employed as a support for ruthenium (Ru/M-MCM41), which could be used as a bifunctional catalyst in the reductive amination of α-keto acids to synthesize α-amino acids. The incorporation of Sr improved the dispersion of Ru nanoparticles and enhanced metal-support interactions via electron transfer from Sr to Ru, and the active Ru sites could efficiently hydrogenate primary imine intermediates to α-amino acids, thus prohibiting the formation of oligomers. Moreover, the Srdopant introduces base sites that could catalyze the hydrolysis of oligomers back to primary imine intermediates and finally hydrogenated to α-amino acids. As a result, >99% yield of glycine was achieved from glyoxylic acid over Ru/Sr-MCM-41, which is nearly three times that achieved over Ru/MCM-41 (32.2%)